Epidemiology and Infection



Disease caused by non-tuberculous mycobacteria in a university hospital in Taiwan, 1997–2003


L. W. DING a1a2 1 , C. C. LAI a1a2 1 , L. N. LEE a1a3 and P. R. HSUEH a1a3c1
a1 Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
a2 Division of Critical Care Medicine, Department of Emergency and Critical Care Medicine, Lotung Poh-Ai Hospital, Yi-Lan, Taiwan
a3 Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan

Article author query
ding lw   [PubMed][Google Scholar] 
lai cc   [PubMed][Google Scholar] 
lee ln   [PubMed][Google Scholar] 
hsueh pr   [PubMed][Google Scholar] 

Abstract

From January 1997 to December 2003, all patients with non-tuberculous mycobacteria (NTM) isolation who were treated at a university hospital in Taiwan were evaluated. Among the 2650 NTM isolates, 1225 (46·2%) were from 412 patients with clinically significant diseases. The annual incidence (per 100000 patients) of disease caused by NTM was 8·96 in 1997, 21·53 in 2002, and 16·55 in 2003. The major types of infections caused by NTM included isolated pulmonary infection and pleurisy (59·5%), skin/soft-tissue infections and osteomyelitis (13·8%), and disseminated diseases (13·3%). The two most common groups of organisms involved were rapidly growing mycobacteria (RGM) (41·4%) and Mycobacterium avium complex (MAC) (39%). The most common organism involved in isolated pulmonary infection and pleurisy was MAC (44·1%). RGM predominated in keratitis (94%), skin/soft-tissue infections and osteomyelitis (43·9%), and lymphadenitis (66·7%). This retrospective 7-year study demonstrated an increase in the incidence of NTM disease in a university hospital.

(Accepted October 17 2005)
(Published Online February 22 2006)


Correspondence:
c1 Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei 100, Taiwan. (Email: hsporen@ha.mc.ntu.edu.tw)


Footnotes

1 These authors contributed equally to this paper.



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