Journal of Hygiene

Research Article

Experimental model of oral antityphoid vaccination with live streptomycin-dependent Salmonella typhimurium in C57BL/6 mice

I. R. Vladoianua1 p1 and F. Dubinia1

a1 Institute of Pharmacology, University of Milan, Medical School, Milan, Italy


The present experimental model offered the opportunity to study particular aspects concerning the avirulence stability of live streptomycin-dependent (Sm D) Salmonella vaccines, under conditions resembling human enteric fever. The results seem to indicate that, in practice, the risk of reversion to a virulent form during oral antityphoid vaccination with Sm D strains remains slight even after the interruption of concomitant streptomycin administration.

(Received February 12 1975)


p1 Present Address: Institute of Medical Microbiology, University of Geneva, 22, Quai E. Anserment, 1211 Geneva 4, Switzerland.