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Organization of ocular dominance and orientation columns in the striate cortex of neonatal macaque monkeys

Published online by Cambridge University Press:  02 June 2009

Gary Blasdel ,
Klaus Obermayer  and
Lynne Kiorpes
Gary Blasdel
Affiliation:
Department of Physiology, University of Calgary, Calgary Alberta, CanadaT2N-1N4 Department of Neurobiology, Harvard Medical School, Boston
Klaus Obermayer
Affiliation:
The Salk Institute, La Jolla The Rockefeller University, New York
Lynne Kiorpes
Affiliation:
Center for Neural Science, New York University, New York
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Abstract

Previous work has shown that small, stimulus-dependent changes in light absorption can be used to monitor cortical activity, and to provide detailed maps of ocular dominance and optimal stimulus orientation in the striate cortex of adult macaque monkeys (Blasdel & Salama, 1986; Ts'o et al., 1990). We now extend this approach to infant animals, in which we find many of the organizational features described previously in adults, including patch-like linear zones, singularities, and fractures (Blasdel, 1992b), in animals as young as 3/12 weeks of age. Indeed, the similarities between infant and adult patterns are more compelling than expected. Patterns of ocular dominance and orientation, for example, show many of the correlations described previously in adults, including a tendency for orientation specificity to decrease in the centers of ocular dominance columns, and for iso-orientation contours to cross the borders of ocular dominance columns at angles of 90 deg. In spite of these similarities, there are differences, one of which entails the strength of ocular dominance signals, which appear weaker in the younger animals and which increase steadily with age. Another, more striking, difference concerns the widths of ocular dominance columns, which increase by 20% during the first 3 months of life. Since the cortical surface area increases by a comparable amount, during the same time, this 20% expansion implies that growth occurs anisotropically, perpendicular to the ocular dominance columns, as the cortical surface expands. Since the observed patterns of orientation preference expand more slowly, at approximately half this rate, these results also imply that ocular dominance and orientation patterns change their relationship, and may even drift past one another, as young animals mature.

Keywords

DevelopmentPrimate striate cortexOcular dominanceOrientation selectivity
Type
Research Articles
Information
Visual Neuroscience , Volume 12 , Issue 3 , May 1995 , pp. 589 - 603
Copyright
Copyright © Cambridge University Press 1995

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