Neuron Glia Biology

Research Article

Cell contact-inhibition signaling as part of wound-healing processes in brain

Ximena A. Lanosaa1 and Jorge A. Colomboa1 c1

a1 Unidad de Neurobiología Aplicada (UNA), CEMIC, Av. Galván 4102 (C1431FWO), Buenos Aires, Argentina

Abstract

Cell contact-dependent signaling is a major regulatory mechanism in the organization of developing tissues and in the reorganization (post-injury responses) of specialized tissues in multicellular organisms. In this review we contribute to the further understanding of post-injury recovery processes in adult nervous tissue. We emphasize evidence that supports the involvement of cell contact-inhibition signaling in the cell proliferation, growth and differentiation that occurs during healing and neural reorganization after brain damage.