European Journal of Anaesthesiology

European Journal of Anaesthesiology (1998), 15:4:433-445 Cambridge University Press
Copyright © 1998 European Society of Anaesthesiology
doi:10.1046/j/1365-2346/1998/00319/x

Original Article
(RD) Surgery

A meta-analysis of nausea and vomiting following maintenance of anaesthesia with propofol or inhalational agents


J. R. Sneyd a1c1, A. Carr a1, W. D. Byrom a2 and A. J. T. Bilski a2
a1 Department of Anaesthesia, Derriford Hospital, Derriford Road, Plymouth PL6 8DH, UK
a2 Zeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire, UK

Article author query
sneyd jr   [PubMed][Google Scholar] 
carr a   [PubMed][Google Scholar] 
byrom wd   [PubMed][Google Scholar] 
bilski ajt   [PubMed][Google Scholar] 

Abstract

A number of prospective randomized comparator studies have suggested that there is a reduction in post-operative nausea and vomiting following maintenance of anaesthesia with propofol compared with inhalational agents. We analysed these studies in more detail by examining the effects of induction agent, choice of inhalation agent, presence/absence of nitrous oxide, age of patient or use of opiate on the incidence of emesis. A search of the Zeneca database MEDLEY was undertaken and prospective randomized comparator studies identified. These were examined individually and independently by two of the authors and log-odds ratios, calculated from the incidence data of each individual trial, were determined and combined using a fixed-effects meta-analysis approach. Patients who received maintenance of anaesthesia with propofol had a significantly lower incidence of post-operative nausea and vomiting in comparison with inhalational agents regardless of induction agent, choice of inhalation agent, presence/absence of nitrous oxide, age of patient or use of opiate.

(Published Online August 16 2006)
(Accepted January 1998)


Key Words: inhalational agents; propofol; nausea; vomiting; meta-Analysis.

Correspondence:
c1 Correspondence: J. R. Sneyd.


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