European Journal of Anaesthesiology

Original Article
(RD) Surgery

Thiopentone and propofol: a compatible mixture?

H. G. W. Paw a1c1, M. Garrood a2, A. J. Fillery-Travis a1a2 and G.T. Rich a2
a1 Department of Anaesthesia, James Paget Hospital, Lowestoft Road, Gorleston, Great Yarmouth NR31 6LA, UK
a2 Institute of Food Research, Norwich Research Park, Colney Lane, Norwich NR4 7UA, UK

Article author query
paw hgw   [PubMed][Google Scholar] 
garrood m   [PubMed][Google Scholar] 
fillery-travis aj   [PubMed][Google Scholar] 
rich gt   [PubMed][Google Scholar] 


The physical compatibility of thiopentone and propofol mixtures was investigated. The investigations used were macroscopic and microscopic observations, zeta potential and oil droplet size measurements. There was no evidence of instability in the mixtures. The thiopentone–propofol mixture has the potential advantage of reducing the pain on injection, provides synergistic interaction, does not prolong recovery when used for induction of anaesthesia, may reduce the incidence of convulsions and is cost-effective.

(Published Online August 16 2006)

Key Words: anaesthetics intravenous; thiopentone; propofol.

c1 Correspondence: H. G. W. Paw, 17 Mander Way, Cambridge CB1 4SF, UK.