Hostname: page-component-8448b6f56d-wq2xx Total loading time: 0 Render date: 2024-04-16T22:05:46.217Z Has data issue: false hasContentIssue false
  • English
  • Français

The effect of propofol on the neutrophil respiratory burst

Published online by Cambridge University Press:  04 August 2006

P. G. Murphy ,
A. J. Ogilvy  and
S. M. Whiteley
P. G. Murphy
Affiliation:
Department of Anaesthesia, The General Infirmary at Leeds, Great George Street, Leeds, UK
A. J. Ogilvy
Affiliation:
University Department of Anaesthesia, Leicester Royal Infirmary, Leicester, UK
S. M. Whiteley
Affiliation:
Department of Anaesthesia, The General Infirmary at Leeds, Great George Street, Leeds, UK
Get access

Abstract

We have examined the effect of propofol on the neutrophil respiratory burst. Chemiluminescence was used as a measure of the respiratory burst following stimulation with 10−5m N-formyl-L-methionyl-L-leucyl-L-phenylalanine.Propofol 1.25, 2.5 and 5.0 × 10−5m inhibited neutrophil chemiluminescence by 29.6, 43.0 and 57.6%, respectively, in neutrophils prepared from healthy adult volunteers, and by 25.5, 37.4 and 54.7% in cells from patients with severe sepsis. We conclude that propofol interferes with the ability of human neutrophils to generate reactive oxygen species.

Keywords

anaestheticsintravenouspropofolneutrophilsrespiratory burst
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 13 , Issue 5 , May 1996 , pp. 471 - 473
Copyright
1996 European Society of Anaesthesiology

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)