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Normal ranges for the variability in heart rate in young infants while sleeping

Published online by Cambridge University Press:  15 August 2006

Martial M. Massin
Affiliation:
Division of Paediatric Cardiology, CHR Citadelle, University of Liège, Belgium
Nadia Withofs
Affiliation:
Division of Paediatric Cardiology, CHR Citadelle, University of Liège, Belgium
Kristel Maeyns
Affiliation:
Division of Paediatric Cardiology, CHR Citadelle, University of Liège, Belgium
Françoise Ravet
Affiliation:
Paediatric Sleep Unit, CHR Citadelle, University of Liège, Belgium
Paul Gérard
Affiliation:
Mathematical Institute, CHR Citadelle, University of Liège, Belgium

Abstract

Objective: Measurements of the variability in heart rate are increasingly used as markers of cardiac autonomic activity. We sought to establish the development this variability in healthy young infants while sleeping. Patients: We carried out polygraphic studies with electrocardiographic recording in 587 healthy infants aged from 5 to 26 weeks. Methods: We determined several variables over a period of 400 minutes sleeping: mean RR interval, 5 time-domain (SDNN, SDNNi, SDANNi, RMSSD, and pNN50) and 5 frequency-domain indexes (spectral power over 3 regions of interest, total power and low-to-high frequency ratio). Frequency-domain indexes were also assessed separately for the periods of quiet sleep and those of rapid eye movement sleep. Results: Our data showed a significant correlation between the indexes of heart rate variability and the mean RR interval, the breathing rate, and the corrected age of the infants. We also demonstrated the importance of the maturation of the sleeping patterns. Conclusion: These data in a large cohort of healthy infants confirm a progressive maturation of the autonomic nervous system during sleep, and may be used to examine the influence of physiological and pathophysiological factors on autonomic control during polygraphic studies.

Type
Original Article
Copyright
2001 Cambridge University Press

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