International Psychogeriatrics

White matter and subcortical gray matter lesion volume changes and late-life depression outcome: a 4-year magnetic resonance imaging study

Po See Chen a1, Douglas R. McQuoid a2, Martha E. Payne a2 and David C. Steffens a2c1
a1 Institute of Basic Medical Sciences and Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
a2 Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, U.S.A.

Article author query
chen ps   [PubMed][Google Scholar] 
mcquoid dr   [PubMed][Google Scholar] 
payne me   [PubMed][Google Scholar] 
steffens dc   [PubMed][Google Scholar] 


Background: Cross-sectional studies have shown that late-onset depression is associated with larger deep white matter lesions (WMLs) and subcortical gray matter lesions (GMLs). In a longitudinal analysis, we examined changes in deep WMLs and subcortical GMLs in older depressed and nondepressed subjects over a 4-year period.

Methods: Brain magnetic resonance imaging (MRI) scans were obtained on 164 depressed and 126 healthy subjects aged 60 years or older at baseline, and 2 and 4 years after recruitment. WMLs and GMLs were measured using a semiautomated technique. We used repeated-measures analysis of covariance to determine cross-sectional lesion volume differences, whether lesion volume changes differed between patients and controls, and the effect of lesion volume changes on outcome in late-life depression.

Results: Mean volumes of lesions for the depressive group were 6.51, 8.18 and 7.75 cm2 for WMLs and 0.23, 0.30 and 0.34 cm2 for GMLs at baseline, 2-year and 4-year follow-up, respectively. Mean volumes of lesions for the control group were 4.83, 6.22 and 6.45 cm2 for WMLs and 0.17, 0.25 and 0.23 cm2 for GMLs at baseline, 2-year and 4-year follow-up, respectively. Cross-sectional between-group mean lesion volumes were significantly different for each measure. However, the pattern of WML and GML volume changes over time was not significantly different between groups. Treatment outcome was associated with changes in total and white matter lesion volume over time.

Conclusions: Lesion volume progression is associated with aging and the pathological condition of late-life depression. The mechanisms that produce these progressive lesion changes remain unclear. Treatments aimed at arresting lesion progression may play a role in the management of late-life depression.

(Received March 2 2005)
(returned for revision April 22 2005)
(revised version received August 18 2005)
(Accepted August 22 2005)
(Published Online February 15 2006)

Key Words: depression; geriatrics; subcortical gray matter lesion; white matter lesion.

c1 Correspondence should be addressed to: David C. Steffens, Duke University Medical Center, Box 3903, Durham, NC 27710, U.S.A. Phone: +1 919 684 3746; Fax: +1 919 681 7668. Email: