Parasitology



Treatment efficacy and regulatory host responses in chronic experimental Schistosoma bovis infections in goats


J. MONRAD a1c1, K. SÖRÉN a2, M. V. JOHANSEN a3, R. LINDBERG a2 and N. ØRNBJERG a3
a1 Danish Centre for Experimental Parasitology, Royal Veterinary and Agricultural University, Dyrlaegevej 100, DK-1870 Frederiksberg C, Denmark
a2 Department of Biomedical Sciences and Veterinary Public Health, Division of Pathology, Pharmacology and Toxicology, Swedish University of Agricultural Sciences, S-75007 Uppsala, Sweden
a3 DBL-Institute for Health Research and Development, Jaegersborg Alle 1D, DK-2920 Charlottenlund, Denmark

Article author query
monrad j   [PubMed][Google Scholar] 
soren k   [PubMed][Google Scholar] 
johansen mv   [PubMed][Google Scholar] 
lindberg r   [PubMed][Google Scholar] 
ornbjerg n   [PubMed][Google Scholar] 

Abstract

The aim of this study was to elucidate the regulatory responses and the long-term effect of praziquantel treatment in chronically Schistosoma bovis-infected West African Dwarf goats. Forty-two goats were used and the design comprised a primary infection followed by treatment at week 13, challenge infection at week 36 and termination at week 52. Dependent variables included clinico-pathological data, worm numbers, faecal and tissue egg counts, and gross pathology of the liver. The results showed that primary infections remained suppressed for up to 52 weeks and, although challenge infections imposed on 36-week-old primary infections established fully, the impairment of their egg production capacity provided protection against clinico-pathological consequences measured by body weight and haemoglobin levels. The study also confirmed a high efficacy (97·7%) of praziquantel for treatment of S. bovis infection in goats and showed that anthelminthic removal of primary infections does not interfere with the ability of the goat to elicit a marked resistance to a subsequent challenge infection. Although treated goats had more fibrous scarring of livers than untreated goats, no negative effects of liver lesions were reflected in weight gains of treated goats. This study provides strong evidence for the beneficial effects of anthelminthic treatment of young domestic stock as an element of treatment and preventive programmes.

(Received December 2 2005)
(Revised February 10 2006)
(Accepted February 11 2006)
(Published Online April 20 2006)


Key Words: Schistosoma bovis; chronic infections; praziquantel treatment; resistance; goats.

Correspondence:
c1 Danish Centre for Experimental Parasitology, Royal Veterinary and Agricultural University, Dyrlaegevej 100, DK-1870 Frederiksberg C, Denmark. Tel: +45 35 282761. Fax: +45 35 282774. E-mail: Jesper.Monrad@vetmi.kvl.dk


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