Journal of the International Neuropsychological Society



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Verbal fluency patterns in amnestic mild cognitive impairment are characteristic of Alzheimer's type dementia


KELLY J.  MURPHY  a1 c1 , JILL B.  RICH  a1 a2 and ANGELA K.  TROYER  a1
a1 Psychology Department, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
a2 Psychology Department, York University, Toronto, Ontario, Canada

Article author query
murphy kj   [PubMed][Google Scholar] 
rich jb   [PubMed][Google Scholar] 
troyer ak   [PubMed][Google Scholar] 

Abstract

Amnestic mild cognitive impairment (aMCI) represents a high-risk factor for Alzheimer's disease (AD) and is characterized by a selective decline in episodic memory. Although by definition aMCI is not associated with impaired verbal fluency performance, we examined relative differences between fluency tasks because AD is characterized by poorer semantic than phonemic fluency. Phonemic and semantic fluency trials were administered to 46 healthy controls, 33 patients with aMCI, and 33 patients with AD. Results revealed a progressive advantage (controls > aMCI > AD) in semantic, relative to phonemic fluency. Difference scores between tasks distinguished each group from the others with medium to large effect sizes (d) ranging from 0.49 to 1.07. Semantic fluency relies more on semantic associations between category exemplars than does phonemic fluency. This aMCI fluency pattern reflects degradation of semantic networks demonstrating that initial neuropathology may extend beyond known early changes in hippocampal regions. (JINS, 2006, 12, 570–574.) a

(Received November 17 2005)
(Revised February 21 2006)
(Accepted February 21 2006)


Key Words: Word generation; Cognitive decline; Semantic memory; Dementia risk; Aging; Language.

Correspondence:
c1 Address correspondence and reprint requests to: Kelly J. Murphy, Ph.D., Psychology Department, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, Ontario, Canada, M6A 2E1. E-mail: kmurphy@baycrest.org


Footnotes

a The data were collected in accordance with the guidelines of the Helsinki Declaration and approved by the Research Ethics and Scientific Review Committee of Baycrest Centre. This is an original submission. Portions of these data were presented at the annual meeting of the International Neuropsychological Society, February 2005, St. Louis, Missouri. There is no conflict of interest.