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Hormone replacement therapy for osteoporosis: clinical and pathophysiological aspects

Published online by Cambridge University Press:  02 March 2009

JE Compston
JE Compston*
Affiliation:
Department of Medicine, University of Cambridge Clinical School, Addenbrooke's Hospital, Cambridge, UK
*
JE Compston, Department of Medicine, University of Cambridge Clinical School, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK
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Extract

The pathogenetic role of oestrogen deficiency in osteoporosis was first postulated by Fuller Albright in 1941 and has subsequently become well established. Hormone replacement therapy prevents menopausal bone loss and is the only treatment which has convincingly been shown to reduce fracture risk at both the spine and hip. The mechanisms by which oestrogens affect bone, however, are poorly understood and many aspects of treatment remain ill-defined, in particular with respect to the duration of therapy and its long-term risks and benefits.

Type
Articles
Information
Reproductive Medicine Review , Volume 3 , Issue 3 , October 1994 , pp. 209 - 224
Copyright
Copyright © Cambridge University Press 1994

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