Journal of the International Neuropsychological Society



Executive dysfunction in substance dependent individuals during drug use and abstinence: An examination of the behavioral, cognitive and emotional correlates of addiction


ANTONIO  VERDEJO-GARCÍA  a1 c1 , ANTOINE  BECHARA  a2 a3 , EMILY C.  RECKNOR  a3 and MIGUEL  PÉREZ-GARCÍA  a1
a1 Depto. Personalidad, Evaluación y Tratamiento Psicológico, and Institute of Neurosciences Federico Olóriz, Universidad de Granada, Granada, Spain
a2 Institute of the Neurological Study of Emotion, Decision-Making, and Creativity, University of Southern California, Los Angeles, USA
a3 Department of Neurology, University of Iowa, Iowa City, Iowa

Article author query
verdejo-garcia a   [PubMed][Google Scholar] 
bechara a   [PubMed][Google Scholar] 
recknor ec   [PubMed][Google Scholar] 
perez-garcia m   [PubMed][Google Scholar] 

Abstract

Increasing evidence indicates that substance-dependent individuals (SDI) are impaired in executive control tasks relying on different systems within the prefrontal cortex (PFC). Three different functional systems have been described: the dorsolateral prefrontal cortex (DLPC), orbitofrontal cortex (OFC), and anterior cingulate cortex (ACC) circuits. Dysfunction within each PFC system is associated with different behavioral, cognitive, and emotional abnormalities. Few studies have conducted an exhaustive examination of all these different factors in SDI. In this study, SDI (including alcohol, cocaine, and methamphetamine polysubstance users, n = 35) were compared with healthy controls (n = 36) on a series of behavioral (Frontal Systems Behaviour Scale, FrSBe), cognitive (N-back, Go-No Go, and Wisconsin Card Sorting Tasks), and emotional (International Affective Picture System, IAPS) tasks, each of which was thought to tax a different component of these PFC functional systems. SDI showed greater behavioral problems in the apathy, disinhibition, and executive dysfunction subscales of the FrSBe. Behavioral deficits were significantly associated with several real-life domains in which SDI typically have problems. SDI also showed poorer performance on cognitive tests of working memory, response inhibition and mental flexibility, and abnormal processing of affective images from the IAPS. Cognitive, behavioral, and emotional measures were moderately correlated. a (JINS, 2006, 12, 405–415.)

(Received June 23 2005)
(Revised December 14 2005)
(Accepted December 15 2005)


Key Words: Apathy; Disinhibition; Executive dysfunction; Dorsolateral prefrontal circuit; Orbitofrontal prefrontal circuit; Anterior cingulate circuit.

Correspondence:
c1 Correspondence and reprint requests to: Antonio Verdejo-García, Departamento de Personalidad, Evaluación y Tratamiento Psicológico. Universidad de Granada. Campus de Cartuja S/N, 18071, Granada, Spain. E-mail: averdejo@ugr.es


Footnotes

a This study was conducted in the Department of Neurology, University of Iowa, Iowa City, USA