Parasitology

Research Article

Changes in parasite aggregation with age: a discrete infection model

R. J. Quinnella1, A. Grafena2 and M. E. J. Woolhousea3

a1 Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT

a2 Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3PS

a3 Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS

SUMMARY

We present a discrete time model for age-related changes in the mean and variance of the number of helminth parasites per host. We assess the degree of aggregation as the negative binomial parameter, k, and use the model to examine the influence of various factors on changes in aggregation with host age: discrete versus continuous infection; the degree of predisposition to infection; infection rate; parasite survival rate; and the variance in exposure to infective stages. The model can produce both increases and decreases in k with host age. However, with parameter values typical of many human helminth infections, a monotonic increase in k (decrease in aggregation) with age is predicted. With an age-dependent infection rate, convex relationships between k and age are possible. These predictions are consistent with data from field studies, but differ from those of previous models which have suggested that k is independent of host age in the absence of density dependence in parasite population dynamics. Differences between the models, and some difficulties in the interpretation of field data, are discussed.

(Received July 29 1994)

(Revised May 11 1995)

(Accepted May 11 1995)

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