The Journal of Laryngology & Otology



Clinical Record

Papillary thyroid carcinoma with exuberant nodular fasciitis-like stroma: treatment outcome and prognosis


Basu a1c1 , Nair a1 , Shet a2 and A M Borges a2
a1 Radiation Medicine Centre, Tata Memorial Hospital, Bombay, India
a2 Department of Pathology, Tata Memorial Hospital, Bombay, India

Article author query
basu s   [PubMed][Google Scholar] 
nair n   [PubMed][Google Scholar] 
shet t   [PubMed][Google Scholar] 
borges am   [PubMed][Google Scholar] 

Abstract

Papillary thyroid carcinoma with nodular fasciitis-like stroma (PTC-NFS) is one of the extremely rare variants of papillary thyroid carcinoma. To date, the majority of reported cases have been published in the surgical pathology and cytopathology literature, addressing the diagnostic difficulties posed by the condition's extensive, reactive stromal proliferation. Because of the rarity of PTC-NFS among papillary thyroid carcinoma variants, it has been unexplored from a clinical viewpoint. A MEDLINE search on the clinical course, role of radioiodine, treatment outcome and long term follow up of this disease yielded no result.

We report the clinicoradiologic and histopathologic profile, together with post-treatment long term follow up, in a 35-year-old woman harbouring this rare entity. To the best of our knowledge, this is the first report of a five-year follow up of this rare variant of PTC following total thyroidectomy and radioiodine treatment. Our follow-up findings reiterate the disease's favourable clinical course when managed in the same manner as a classical, differentiated papillary carcinoma of the thyroid, akin to that predicted by the pathologists, and emphasize the importance of differentiating PTC-NFS as a separate entity from the papillary carcinoma variants with aggressive histology. Given the rarity of this condition, the experience gained from the present case is a useful addition to the current knowledge on disease prognostication and management.

A systematic review of the existing literature on PTC-NFS, including the case reported in the present paper, is also carried out, aiming to explore the patient characteristics and clinical behaviour pattern of this rare entity and to make appropriate recommendations on management strategy. The age of presentation ranges from 20 to 82 years, with a mean of 44.5 years. Female preponderance was observed, with a female to male ratio of 3[ratio]1. No racial predilection was observed. Tumour size varied from 2 to 9 cm along its greatest diameter (mean = 4.3 cm). Metastasis to lymph nodes at presentation occurred in 25 per cent of cases. Metastasis to surrounding structures (e.g. parathyroid and skeletal muscle) was observed in 12.5 per cent. There have been no reports of pulmonary or skeletal metastasis at presentation.

(Published Online February 16 2006)
(Accepted August 8 2005)


Key Words: Carcinoma; Papillary; Thyroid Neoplasms.

Correspondence:
c1 Address for correspondence: Dr Sandip Basu, c/o Radiation Medicine Centre, Tata Memorial Centre Annexe, Jerbai Wadia Road, Parel, Bombay 400 012, India. E-mail: drsanb@yahoo.com


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