International Journal of Technology Assessment in Health Care

Research Notes

Drugs for AIDS/HIV: Assessing the Evidence

Jan L. Jonesa1

a1 Scottish Health Purchasing Information Centre


This article highlights factors that may cause bias in individual controlled trials or meta-analysis of zidovudine (AZT) in HIV disease. The overall benefit of AZT and antiretroviral drug combinations in the progression of HIV disease is probably greater than has been or can ever be shown in an ethical controlled trial.