Parasitology

Research Article

Iron status of schoolchildren with varying intensities of Trichuris trichiura infection

D. D. Ramdatha1 p1, D. T. Simeona1, M. S. Wonga1 and S. M. Grantham-McGregora1

a1 Tropical Metabolism Research Unit, University of the West Indies, Mono, Kingston 7, Jamaica

SUMMARY

The relationship between varying intensities of Trichuris trichiura infection and iron status was examined in Jamaican schoolchildren, aged 7 to 11 years. A total of 409 children was identified with T. trichiura (epg > 1200). A control group comprised 207 uninfected children who were matched by school and class to every pair of infected subjects. Blood samples were obtained from 421 children: 264 infected and 157 controls. Compared to the rest of the children, those with heavy infections (epg > 10 000) had significantly lower (P < 0·05) Hb (11·5 ± 1·3 vs. 12·1 ± 1·1 g/dl), MCV (78·6 ± 6·3 vs. 81·2 ± 5·5 fl), MCH (26·2 ± 2·9 vs. 27·5 ± 2·5 pg) and MCHC (33·2 ± 1·5 vs. 33·9 ± 1·4 g/dl). Similarly, the prevalence of anaemia (Hb < 11·0 g/dl) amongst heavily infected children (33%) was significantly higher (P < 0·05) than the rest of the sample (11%). These differences remained significant after controlling for confounding variables including socio-economic status, age, gender, area of residence and the presence of Ascaris infections. Differences in red cell count, ferritin, and free erythrocyte protoporphyrin were not statistically significant and showed no association with the infectious load. These results suggest that in the Jamaican children studied, iron deficiency anaemia is associated with Trichuris infections over 10 000 epg, but not with less intense infections.

(Received May 25 1994)

(Revised August 25 1994)

(Accepted August 25 1994)

Correspondence:

p1 Present address and address for reprint requests: Dr D. D. Ramdath, Department of Biochemistry, Faculty of Medical Sciences, University of the West Indies, St Augustine, Trinidad and Tobago.

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