Quarterly Reviews of Biophysics

Research Article

Computational challenges for macromolecular structure determination by X-ray crystallography and solution NMRspectroscopy

Axel T. Brüngera1 and Michael Nilgesa2

a1 Howard Hughes Medical Institute and Department of Molecular Biophysics and Biochemistry, Yale University, New Haven CT 06511, USA

a2 European Molecular Biology Laboratory, Meyerhofstr. 1, D-6900 Heidelberg, FRG

Macromolecular structure determination by X-ray crystallography and solution NMR spectroscopy has experienced unprecedented growth during the past decade.