Quarterly Reviews of Biophysics

Research Article

Soft X-ray microscopes and their biological applications

Janos Kirza1, Chris Jacobsena1 and Malcolm Howellsa2

a1 Physics Department, State University of New York, Stony Brook, NY 11794–3800 USA

a2 Advanced Light Source, Lawrence Berkeley Laboratory, Berkeley, CA 94720 USA

In this review we propose to address the question: for the life-science researcher, what does X-ray microscopy have to offer that is not otherwise easily available?

We will see that the answer depends on a combination of resolution, penetrating power, analytical sensitivity, compatibility with wet specimens, and the ease of image interpretation.