Quarterly Reviews of Biophysics

Research Article

Protein folding

George Némethya1 and Harold A. Scheragaa1

a1 Department of Chemistry, Cornell University, Ithaca, New York 14853 (U.S.A.)

This review describes recent advances in studies on the stabilities of the three-dimensional structures of proteins and on the processes leading to the formation of these structures. The term ‘protein folding’ will be used here to denote the process of the conversion of an open polypeptide chain into the unique three-dimensional conformation of the native protein. Experimental and theoretical aspects of protein folding have been reviewed by anfinsen & Scheraga (1975). In the present article, we emphasize advances made since the writing of that review, together with a brief summary of the background of recent studies.