Parasitology

Research Article

Experimental evidence of genetic determinism in high susceptibility to intestinal pinworm infection in mice: a hybrid zone model

C. Mouliaa1, N. Le Bruna1, J. Dallasa2, A. Ortha2 and F. Renauda1

a1 Laboratoire de Parasitologic Comparée (URA 698, CNRS), Université de Montpellier II, Place E. Bataillon, 34 095 Montepellier cédex 5, France

a2 Equipe ‘Génome et Populations’ (URA 1493, CNRS), Université de Montpellier II, Place E. Bataillon, 34 095 Montepellier cédex 5, France

SUMMARY

In the hybrid zone of the two mouse subspecies Mus musculus musculus and Mus musculus domesticus, mice with hybrid genotypes harbour, on the average, more helminth parasites (cestodes and nematodes) than mice of the two parental taxa. In order to determine the roles played by genetic parameters in this phenomenon, mice with recombined and parental genotypes were experimentally infected with the intestinal pinworm Aspiculuris tetraptera, a natural parasite of the house mouse. The results showed that the high susceptibility of the hybrid zone mice is genetically determined. In addition, this study shows the occurrence of variability among resistant parental populations.

(Received March 18 1992)

(Revised September 29 1992)

(Accepted September 29 1992)

Key words

  • hybrid zone;
  • mice;
  • intestinal pinworms;
  • Aspiculuris tetraptera;
  • susceptibility;
  • genetic determinism.
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