Journal of the International Neuropsychological Society

Research Article

Subjective complaints of cognitive symptoms are related to psychometric findings of memory deficits in patients with HIV-1 infection

Erja Poutiainena1 and Irina Elovaaraa2

a1 Departments of Neurology and Psychology, University of Helsinki, Finland

a2 Department of Neurology, University of Tampere, Finland

Abstract

Eighty-five subjects at various stages of human immunodeficiency virus (HIV-1) infection and 39 seronegative controls underwent neurological and neuropsychological evaluation to assess the relationship between cognitive test results and subjective complaints (cognitive, affective, motor, and other). The effect of psychiatric disorders on the association between cognitive performance and complaints of the patients was also examined. Patients with symptomatic infection had higher frequency of complaints than subjects at asymptomatic stage. Detailed neuropsychological examination confirmed a strong association between poor verbal memory and cognitive complaints. Poor performance on cognitive speed and flexibility was associated with motor complaints and motor abnormalities. These associations were not explained by psychiatric disorders or elevated depression questionnaire scores. Our observations indicate that, especially in symptomatic HIV-1 infection, cognitive changes reported by patients often reflect “objective” cognitive decline, and may be the earliest signs of HIV-1 associated cognitive disorder. No direct relationship was observed between “subjective” complaints and neuropsychological performance of asymptomatic subjects. Understanding the significance of reported cognitive changes have important therapeutic implications. (JINS, 1996, 2, 219–225.)

(Received September 01 1994)

(Accepted July 12 1995)

Footnotes

Reprint requests to: Erja Poutiainen. Department of Neurology, Helsinki University Hospital, SF–00290 Helsinki, Finland.