Research Article

The effect of repeated chemotherapy on age-related predisposition to Ascaris lumbricoides and Trichuris trichiura

L. Chana1, S. P. Kana2 and D. A. P. Bundya1

a1 Parasite Epidemiology Research Group, Department of Biology, Imperial College, London SW7 2BB, UK

a2 Department of Parasitology, Faculty of Medicine, University of Malaya, 59100 Kuala Lumpur, Malaysia


This study examines the persistence of predisposition to Ascaris lumbricoides and Trichuris trichiura during repeated chemotherapy in an urban community in Kuala Lumpur, Malaysia. Significant predisposition was observed over 2 periods of reinfection with and without age-standardization of data. Analysis of different age groups indicated that predisposition was most strongly detectable in the younger age classes. The intensities of infection with both parasites were strongly correlated at each cycle of intervention, suggesting that individuals were similarly predisposed to both species.

(Received June 26 1991)

(Revised October 05 1991)

(Accepted October 05 1991)