Psychological Medicine



Original Article

Preliminary evidence that gonadal hormones organize and activate disordered eating 1


KELLY L. KLUMP a1c1, KYLE L. GOBROGGE a2, PATRICK S. PERKINS a1, DAVID THORNE a3, CHERYL L. SISK a4 and S. MARC BREEDLOVE a4
a1 Department of Psychology, Michigan State University, East Lansing, MI, USA
a2 Neuroscience Program, Department of Psychology, Florida State University, Tallahassee, FL, USA
a3 Medical Technology Program, Michigan State University, East Lansing, MI, USA
a4 Neuroscience Program and Department of Psychology, Michigan State University, East Lansing, MI, USA

Article author query
klump kl   [PubMed][Google Scholar] 
gobrogge kl   [PubMed][Google Scholar] 
perkins ps   [PubMed][Google Scholar] 
thorne d   [PubMed][Google Scholar] 
sisk cl   [PubMed][Google Scholar] 
breedlove sm   [PubMed][Google Scholar] 

Abstract

Objective. Eating disorders are more common in females than in males. Gender differences may be due to organizational (i.e. prenatal) and activational (i.e. post-natal) gonadal hormone effects that influence sex differences in behavior. This preliminary set of studies examined these effects by investigating relationships between eating disorder symptoms, prenatal testosterone exposure, and adult levels of estrogen in women.

Method. We examined organizational associations by investigating relationships between disordered eating and finger-length ratios, which are known to be somatic markers of prenatal testosterone exposure. Participants included 113 adult female twins drawn from the community. Disordered eating was assessed with the total score from the Minnesota Eating Behavior Survey (MEBS). Finger lengths were hand scored using a ruler and photocopies of both hands. We also investigated activational influences by examining associations between circulating levels of estradiol and disordered eating symptoms. Two independent samples of adult females (n's=24 and 25) drawn from the community were used for this study. Disordered eating was again assessed with the MEBS total score, while saliva samples were used for assessing estradiol.

Results. Positive associations were found between disordered eating and both finger-length ratios and circulating estradiol levels.

Conclusions. Findings suggest that lower levels of prenatal testosterone exposure and higher adult levels of estradiol are associated with increased eating disorder symptoms. We hypothesize that the relatively low level of testosterone before birth in females permits their brains to respond to estrogens at puberty, when the hormones activate the genes contributing to disordered eating in vulnerable girls.


Correspondence:
c1 Department of Psychology, Michigan State University, 107B Psychology Building, East Lansing, MI 48824-1116, USA. (Email: klump@msu.edu)


Footnotes

1 Parts of this paper were presented at the Academy for Eating Disorders Conference, Denver, CO, in May 2003 and the New York Academy of Sciences Meeting, New York, NY, in September 2003.



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