Palliative & Supportive Care



The impact of a multidimensional exercise program on self-reported anxiety and depression in cancer patients undergoing chemotherapy: A phase II study


JULIE  MIDTGAARD  a1 c1 , MIKAEL  RØRTH  a2 , REINHARD  STELTER  a3 , ANDERS  TVETERÅS  a1 , CHRISTINA  ANDERSEN  a2 , MORTEN  QUIST  a1 , TOM  MØLLER  a4 and LIS  ADAMSEN  a1
a1 The University Hospitals Centre for Nursing and Care Research (UCSF), Copenhagen University Hospital, Department 7331, Blegdamsvej 9, DK-2100 Copenhagen O, Denmark
a2 Department of Oncology, Copenhagen University Hospital, Department 5073, Blegdamsvej 9, DK-2100 Copenhagen O, Denmark
a3 University of Copenhagen, Institute of Exercise and Sport Sciences, Nørre Allé 51, DK-2200 Copenhagen N, Denmark
a4 Department of Hematology, Copenhagen University Hospital, Department 4042, Blegdamsvej 9, DK-2100 Copenhagen O, Denmark

Article author query
midtgaard j   [PubMed][Google Scholar] 
rorth m   [PubMed][Google Scholar] 
stelter r   [PubMed][Google Scholar] 
tveteras a   [PubMed][Google Scholar] 
andersen c   [PubMed][Google Scholar] 
quist m   [PubMed][Google Scholar] 
moller t   [PubMed][Google Scholar] 
adamsen l   [PubMed][Google Scholar] 

Abstract

Little is known about the role of exercise in improving cancer patients' mood while undergoing chemotherapy. In this phase II study changes in self-reported anxiety and depression and fitness (VO2max) are reported in relation to a 6-week, 9 h weekly, multidimensional exercise program. A total of 91 patients receiving chemotherapy, between 18 and 65 years old, completed a Hospital Anxiety and Depression Scale Questionnaire (HADS; response rate 91%, adherence rate 78%). Anxiety (p < 0.001) and depression (p = 0.042) was significantly reduced. The mean ± SD of the change was −1.14 ± 2.91 for anxiety and −0.44 ± 2.77 for depression. Improvements in fitness were correlated with improvements in depression, [chi]2(1) = 3.966, p = 0.046, but not with improvements in anxiety, [chi]2(1) = 0.540, p = 0.462. The research suggests that exercise intervention may have a beneficial impact on psychological distress for cancer patients receiving chemotherapy with low to moderate levels of baseline psychomorbidity. The study furthermore indicates that changes in distress may be associated with disease status and levels of physical activity undertaken during disease. The study is followed up by an ongoing randomized clinical controlled trial to evaluate potential causal effects of exercise intervention on psychological distress and fitness in cancer patients undergoing chemotherapy.

(Received March 6 2005)
(Accepted April 3 2005)


Key Words: Cancer; Chemotherapy; Multidimensional exercise program; Anxiety; Depression.

Correspondence:
c1 Corresponding author: Julie Midtgaard, MscPsych, Psychologist, PhD Student, The University Hospitals Centre for Nursing and Care Research (UCSF), Copenhagen University Hospital, Department 7331, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. E-mail: ucsf@ucsf.dk