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Cross-design Synthesis: A New Form of Meta-analysis for Combining Results from Randomized Clinical Trials and Medical-practice Databases

Published online by Cambridge University Press:  10 March 2009

Judith Droitcour ,
George Silberman  and
Eleanor Chelimsky
Judith Droitcour
Affiliation:
U.S. General Accounting Office
George Silberman
Affiliation:
U.S. General Accounting Office
Eleanor Chelimsky
Affiliation:
U.S. General Accounting Office
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Abstract

Cross-design synthesis is a new (and still evolving) strategy for providing quantitative results that capture the strengths and minimize the weaknesses of different kinds of research. The strategy, which is being developed to answer questions about the effects of treatment in medical practice, includes (a) identifying complementary research designs and studies conducted according to those designs; (b) completing an in-depth assessment of each study with respect to the chief potential bias(es) that are associated with its design; (c) making “secondary adjustments” of study results to correct known biases; and (d) developing synthesis frameworks and models that will minimize the impact of hidden biases.

Type
Statistics
Information
International Journal of Technology Assessment in Health Care , Volume 9 , Issue 3 , Summer 1993 , pp. 440 - 449
Copyright
Copyright © Cambridge University Press 1993

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