Genetical Research



Chromosomal phylogeny of Robertsonian races of the house mouse on the island of Madeira: testing between alternative mutational processes


JANICE BRITTON-DAVIDIAN a1c1, JOSETTE CATALAN a1, MARIA DA GRAÇA RAMALHINHO a2, JEAN-CHRISTOPHE AUFFRAY a1, ANA CLAUDIA NUNES a3, ELODIE GAZAVE a1, JEREMY B. SEARLE a4 and MARIA DA LUZ MATHIAS a3
a1 Institut des Sciences de l'Evolution, UMR 5554, Laboratoire Génétique et Environnement, CC65, Université Montpellier II, 34095 Montpellier Cedex 5, France
a2 Centro de Biologia Ambiental, Museu Bocage, Universidade de Lisboa, Rua da Escola Politécnica, 1268-102 Lisbon, Portugal
a3 Centro de Biologia Ambiental, Departamento de Biologia Animal, Faculdade de Ciências, Universidade de Lisboa, Edifício C 2, 3 ° Piso, Campo Grande, 1749-016 Lisbon, Portugal
a4 Department of Biology, University of York, PO Box 373, York YO10 5YW, UK

Article author query
britton-davidian j   [PubMed][Google Scholar] 
catalan j   [PubMed][Google Scholar] 
ramalhinho md   [PubMed][Google Scholar] 
auffray jc   [PubMed][Google Scholar] 
claudia nunes a   [PubMed][Google Scholar] 
gazave e   [PubMed][Google Scholar] 
searle jb   [PubMed][Google Scholar] 
mathias md   [PubMed][Google Scholar] 

Abstract

The ancestral karyotype of the house mouse (Mus musculus) consists of 40 acrocentric chromosomes, but numerous races exist within the domesticus subspecies characterized by different metacentric chromosomes formed by the joining at the centromere of two acrocentrics. An exemplary case is present on the island of Madeira where six highly divergent chromosomal races have accumulated different combinations of 20 metacentrics in 500–1000 years. Chromosomal cladistic phylogenies were performed to test the relative performance of Robertsonian (Rb) fusions, Rb fissions and whole-arm reciprocal translocations (WARTs) in resolving relationships between the chromosomal races. The different trees yielded roughly similar topologies, but varied in the number of steps and branch support. The analyses using Rb fusions/fissions as characters resulted in poorly supported trees requiring six to eight homoplasious events. Allowance for WARTs considerably increased nodal support and yielded the most parsimonious trees since homoplasy was reduced to a single event. The WART-based trees required five to nine WARTs and 12 to 16 Rb fusions. These analyses provide support for the role of WARTs in generating the extensive chromosomal diversification observed in house mice. The repeated occurrence of Rb fusions and WARTs highlights the contribution of centromere-related rearrangements to accelerated rates of chromosomal change in the house mouse.

(Received May 25 2005)
(Revised August 30 2005)


Correspondence:
c1 Tel: +33 4 67143910. Fax: +33 4 67143622. e-mail: britton@isem.univ-montp2.fr


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