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Molecular and serological characterization of adenovirus genome type 7h isolated in Japan

Published online by Cambridge University Press:  01 April 1999

M. HASHIDO ,
A. MUKOUYAMA ,
K. SAKAE ,
H. TSUZUKI ,
T. YAMASHITA ,
T. INADA  and
S. INOUYE
M. HASHIDO
Affiliation:
Infectious Diseases Surveillance Center, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan
A. MUKOUYAMA
Affiliation:
Infectious Diseases Surveillance Center, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan
K. SAKAE
Affiliation:
Department of Virology, Aichi Prefectural Institute of Public Health, Nagoya, Japan
H. TSUZUKI
Affiliation:
Department of Virology, Aichi Prefectural Institute of Public Health, Nagoya, Japan
T. YAMASHITA
Affiliation:
Department of Virology, Aichi Prefectural Institute of Public Health, Nagoya, Japan
T. INADA
Affiliation:
Infectious Diseases Surveillance Center, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan
S. INOUYE
Affiliation:
Infectious Diseases Surveillance Center, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan
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Abstract

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In 1996, three adenovirus type 7 (Ad7) strains were isolated from children with fever and upper respiratory diseases in Japan. Restriction endonucleases (REs) analysis and PCR amplification of the E3 7·7 kDa ORF revealed that these strains were genotype Ad7h and closely related to an Argentine Ad7h strain, which has been reported to be highly virulent and so far predominant only in South America. These strains showed weak cross-neutralizing activity and specific haemagglutination-inhibition activity to Ad3 antiserum. The present findings suggest that Ad7h in South America has spread to other parts of the world. Since the seroprevalence to Ad7 in the current Japanese population is very low due to the absence of Ad7 circulation in Japan for decades, Ad7 outbreak as a typical case of re-emerging infectious diseases is a cause for serious concern.

Type
Research Article
Information
Epidemiology & Infection , Volume 122 , Issue 2 , April 1999 , pp. 281 - 286
Copyright
© 1999 Cambridge University Press