Epidemiology and Infection



Determinants of antibodies to Cryptosporidium infection among gay and bisexual men with HIV infection


C. CAPUTO a1, A. FORBES a1, F. FROST a2, M. I. SINCLAIR a1, T. R. KUNDE a2, J. F. HOY a3 and C. K. FAIRLEY a1a3c1
a1 Department of Epidemiology and Preventive Medicine, Monash University, The Alfred Hospital, Victoria, Australia
a2 Southwest Center for Managed Care Research (SCMCR), Albuquerque, New Mexico, USA
a3 Department of Infectious Diseases, The Alfred Hospital, Victoria, Australia

Abstract

A cross-sectional serosurvey for markers of prior Cryptosporidium infection was conducted among homosexual or bisexual males infected with human immunodeficiency virus (HIV); of 262 individuals approached, 236 (90%) agreed to participate. Serological response to two Cryptosporidium antigens was measured using a Western blot assay. The intensity or detection of serological responses to two Cryptosporidium antigens was not associated with CD4 cell counts or tap water consumption. A number of sexual practices were related to increased serological response for only the 27-kDa marker, including having had sex within the past 2 years, having anal sex and having had a larger number of sex partners during the past 2 years. Attending a spa or sauna was related to serological response to both the 27-kDa and 17-kDa markers. Based on these results, activities related to sexual activity appear to be a significant risk factors for prior Cryptosporidium infection.

(Accepted November 25 1998)


Correspondence:
c1 Author for correspondence: Department of Epidemiology and Preventive Medicine, Monash University, The Alfred Hospital, Prahran, VIC 3181 Australia.


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