Hostname: page-component-7c8c6479df-27gpq Total loading time: 0 Render date: 2024-03-28T18:28:06.850Z Has data issue: false hasContentIssue false

A two-year follow-up survey of antibody to Cryptosporidium in Jackson County, Oregon following an outbreak of waterborne disease

Published online by Cambridge University Press:  01 August 1998

F. J. FROST
Affiliation:
Southwest Center for Managed Care Research, 2425 Ridgewest Drive SE, Albuquerque, New Mexico 87108, USA
R. L. CALDERON
Affiliation:
US EPA National Health and Environment Effects Research Laboratory, Research Triangle Park, North Carolina
T. B. MULLER
Affiliation:
Southwest Center for Managed Care Research, 2425 Ridgewest Drive SE, Albuquerque, New Mexico 87108, USA
M. CURRY
Affiliation:
Southwest Center for Managed Care Research, 2425 Ridgewest Drive SE, Albuquerque, New Mexico 87108, USA
J. S. RODMAN
Affiliation:
Southwest Center for Managed Care Research, 2425 Ridgewest Drive SE, Albuquerque, New Mexico 87108, USA
D. M. MOSS
Affiliation:
CDC Immunology Branch, Division of Parasitic Diseases, Atlanta, Georgia
A. A. de la CRUZ
Affiliation:
US EPA National Exposure Assessment Laboratory, Cincinnati, Ohio
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

To estimate the duration of Cryptosporidium-specific antibody, a Western blot assay measured antibody in paired sera from 124 residents of Jackson County, Oregon collected 0·5 and 2·5 years after the end of an outbreak in Talent, Jackson County. The outcome measure was the intensity of antibody responses, (which may approximate to a titre), to 27-kDa and 15/17-kDa antigens. Intensity of response to the 27-kDa antigen(s) declined to 54% of the 1992 value while responses to a 15/17-kDa antigen(s) remained close to the initial values. Increasing age of the donor predicted higher intensity of antibody to the 15/17-kDa antigen(s) in both the initial (P=0·004) and follow-up (P=0·038) surveys. No relationship was observed between age and antibody intensity for the 27-kDa antigen(s) during either survey (P>0·10). Both the initial and follow-up surveys showed significant elevations in antibody intensity for Talent residents, possibly indicating a high endemic rate of infection/re-infection or high levels of chronic infection.

Type
Research Article
Copyright
© 1998 Cambridge University Press