Epidemiology and Infection

Absence of relationship between Schistosoma japonicum and hepatitis B virus infection in the Dongting lake region, China

X.-P. YE a1c1, Y.-L. FU a2, R. M. ANDERSON a1 and D. J. NOKES a3
a1 The Wellcome Trust Centre for the Epidemiology of Infectious Disease, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
a2 Yujiang Hospital of Schistosomiasis, Yujiang, Hunan, China
a3 Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK


In order to determine whether infection with Schistosoma japonicum is related to a higher rate of infection with hepatitis B virus and/or to a higher probability of HBsAg chronic carriage, a population based survey was carried out in China in which HBV markers were studied in 112 subjects with long-lasting S. japonicum infection, and 93 subjects with no S. japonicum infection 37·5% of the cases and 40·9% of controls showed no markers of HBV infection. The prevalence rate of HBsAg was 12·5% in the cases and 12·9% in the controls. For anti-HBc and anti-HBs the figures were 59·8% and 59·8%, and 27·9% and 35·0%, respectively. These data do not support the hypothesis of an interaction between infection with hepatitis B virus and S. japonicum.

(Accepted February 4 1998)

c1 Author for correspondence.