Epidemiology and Infection



Association of a disease approximating cholera caused by Vibrio cholerae of serogroups other than O1 and O139


M. K. BHATTACHARYA a1c1, D. DUTTA a1, S. K. BHATTACHARYA a1, A. DEB a1, A. K. MUKHOPADHYAY a1, G. B. NAIR a1, T. SHIMADA a2, Y. TAKEDA a3, A. CHOWDHURY a4 and D. MAHALANABIS a5
a1 National Institute of Cholera & Enteric Diseases, P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta – 700 010
a2 National Institute of Infectious Diseases, Shinjuku-ku, Tokyo 162, Japan
a3 Research Institute, International Medical Center of Japan, Tokyo 162, Japan
a4 I.D. Hospital, Beliaghata, Calcutta – 700 010
a5 Society for Applied Study, 108, Manicktala Main Road, Suite 3/21, Calcutta – 700 054, India

Abstract

One hundred and six patients suffering from severe dehydrating diarrhoea were studied of whom 36 patients were positive for Vibrio cholerae. Out of 36, 15 were positive for V. cholerae O1, 10 for V. cholerae O139 and 11 for V. cholerae non-O1 non-O139. O1 and O139 were positive for the 301-bp ctxA amplicon and 471-bp tcpA amplicon indicating that the strains possessed toxigenic capability whereas no non-O1 non-O139 strain possessed ctxA or tcpA genes. Post-admission severity of purging and amount of ORS required were less in the V. cholerae non-O1 non-O139 group (P<0·05) compared to the V. cholerae O1 and O139 groups. It appears from this study that a cholera-like clinical condition can be caused in the absence of CT as exemplified by strains of non-O1 non-O139.

(Accepted September 17 1997)


Correspondence:
c1 Author for correspondence: National Institute of Cholera & Enteric Diseases, P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta – 700 010, India.


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