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Association of a disease approximating cholera caused by Vibrio cholerae of serogroups other than O1 and O139

Published online by Cambridge University Press:  01 February 1998

M. K. BHATTACHARYA ,
D. DUTTA ,
S. K. BHATTACHARYA ,
A. DEB ,
A. K. MUKHOPADHYAY ,
G. B. NAIR ,
T. SHIMADA ,
Y. TAKEDA ,
A. CHOWDHURY  and
D. MAHALANABIS
M. K. BHATTACHARYA
Affiliation:
National Institute of Cholera & Enteric Diseases, P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta – 700 010
D. DUTTA
Affiliation:
National Institute of Cholera & Enteric Diseases, P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta – 700 010
S. K. BHATTACHARYA
Affiliation:
National Institute of Cholera & Enteric Diseases, P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta – 700 010
A. DEB
Affiliation:
National Institute of Cholera & Enteric Diseases, P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta – 700 010
A. K. MUKHOPADHYAY
Affiliation:
National Institute of Cholera & Enteric Diseases, P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta – 700 010
G. B. NAIR
Affiliation:
National Institute of Cholera & Enteric Diseases, P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta – 700 010
T. SHIMADA
Affiliation:
National Institute of Infectious Diseases, Shinjuku-ku, Tokyo 162, Japan
Y. TAKEDA
Affiliation:
Research Institute, International Medical Center of Japan, Tokyo 162, Japan
A. CHOWDHURY
Affiliation:
I.D. Hospital, Beliaghata, Calcutta – 700 010
D. MAHALANABIS
Affiliation:
Society for Applied Study, 108, Manicktala Main Road, Suite 3/21, Calcutta – 700 054, India
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Abstract

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One hundred and six patients suffering from severe dehydrating diarrhoea were studied of whom 36 patients were positive for Vibrio cholerae. Out of 36, 15 were positive for V. cholerae O1, 10 for V. cholerae O139 and 11 for V. cholerae non-O1 non-O139. O1 and O139 were positive for the 301-bp ctxA amplicon and 471-bp tcpA amplicon indicating that the strains possessed toxigenic capability whereas no non-O1 non-O139 strain possessed ctxA or tcpA genes. Post-admission severity of purging and amount of ORS required were less in the V. cholerae non-O1 non-O139 group (P<0·05) compared to the V. cholerae O1 and O139 groups. It appears from this study that a cholera-like clinical condition can be caused in the absence of CT as exemplified by strains of non-O1 non-O139.

Type
Research Article
Information
Epidemiology & Infection , Volume 120 , Issue 1 , February 1998 , pp. 1 - 5
Copyright
© 1998 Cambridge University Press