Epidemiology and Infection

Molecular analysis of foot-and-mouth disease type O viruses isolated in Saudi Arabia between 1983 and 1995

A. R. SAMUEL a1c1, N. J. KNOWLES a1, R. P. KITCHING a1 and S. M. HAFEZ a2
a1 OIE/FAO World Reference Laboratory for Foot-and-Mouth Disease, Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Woking, Surrey, GU24 0NF, UK
a2 c/o National Agriculture and Water Research Centre, PO Box 17285, Riyadh 11484, Saudi Arabia


Partial nucleotide sequence of the capsid polypeptide coding gene 1D (VP1) was determined for 68 serotype O foot-and-mouth disease viruses isolated between 1983 and 1995 from outbreaks occurring in Saudi Arabia. The sequences were compared with previously published sequences: 14 viruses of Middle Eastern origin (isolated between 1987 and 1991); and with four vaccine virus strain sequences, three originating from the Middle East (O1/Turkey/Manisa/69, O1/Sharquia/Egypt/72 and O1/Israel/2/85) and one from Europe (O1/BFS 1860/UK/67). The virus isolates from Saudi Arabia and the Middle East vaccine virus strains formed a related genetic group distinct from the European O1virus. Within this large group 12 distinct genetic sublineages were observed.

(Accepted September 30 1996)

c1 Author for correspondence.