Epidemiology and Infection



Co-existence of cerebral cysticercosis with Japanese encephalitis: a prognostic modulator


A. DESAI a1, S. K. SHANKAR a2, P. N. JAYAKUMAR a3, A. CHANDRAMUKI a1, M. GOURIE-DEVI a4, B. V. RAVIKUMAR a5 and V. RAVI a1
a1 Department of Neurovirology, National Institute of Mental Health & Neuro Sciences, Bangalore 560029, India
a2 Department of Neuropathology, National Institute of Mental Health & Neuro Sciences, Bangalore 560029, India
a3 Department of Neuroradiology, National Institute of Mental Health & Neuro Sciences, Bangalore 560029, India
a4 Department of Neurology, National Institute of Mental Health & Neuro Sciences, Bangalore 560029, India
a5 Astra Research Centre India, Bangalore 560003, India

Abstract

In this study, we investigated the frequency of co-existence of cerebral cysticercosis (CC) in Japanese encephalitis (JE) cases with special emphasis on its role in predicting the final clinical outcome. Amongst the 163 confirmed cases of JE, 37·42% (61/163) had co-existent CC. This was confirmed by antibody detection in the CSF of 45 cases, CT scan of the brain in 6 cases and at autopsy in 3 cases. In 2 cases confirmation was possible by CT scan as well as at autopsy, in 4, CSF antibody levels and CT scan were suggestive of CC while in 1, CSF antibodies and autopsy were suggestive of CC. The co-occurrence of Cysticercus cellulosae in the brain emerged as a prognosticator of poor outcome in JE cases (P<0·03).

(Accepted October 12 1996)


Correspondence:
Present address: XCyton Diagnostics Pvt Ltd, Bangalore 560094, India.
Correspondence and reprint requests: Dr V. Ravi, Associate Professor, Department of Neurovirology, NIMHANS, Bangalore 560029, India.


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