Journal of Helminthology

Research Papers

In vitro effects of artesunate on the survival of worm pairs and egg production of Schistosoma mansoni

Y. Mitsuia1 c1, M. Miuraa1 and Y. Aokia1

a1 Department of Parasitology, Institute of Tropical Medicine, Nagasaki University, Sakamoto, Nagasaki, 852-8523 Japan


The effect of artesunate (ART) on the survival time of adult worm pairs of Schistosoma mansoni and on their egg output during in vitro culture was assessed. ART significantly decreased the survival time of both paired male and female worms at concentrations of 5, 10, 20 and 40 mg l− 1 during in vitro cultivation. An inhibitory effect of ART on the daily egg output of paired female worms during in vitro cultivation was also observed.

(Accepted July 30 2008)

(Online publication October 10 2008)


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