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In vitro effects of artesunate on the survival of worm pairs and egg production of Schistosoma mansoni

Published online by Cambridge University Press:  01 March 2009

Y. Mitsui ,
M. Miura  and
Y. Aoki
Y. Mitsui*
Affiliation:
Department of Parasitology, Institute of Tropical Medicine, Nagasaki University, Sakamoto, Nagasaki, 852-8523Japan
M. Miura
Affiliation:
Department of Parasitology, Institute of Tropical Medicine, Nagasaki University, Sakamoto, Nagasaki, 852-8523Japan
Y. Aoki
Affiliation:
Department of Parasitology, Institute of Tropical Medicine, Nagasaki University, Sakamoto, Nagasaki, 852-8523Japan
*
*Fax: +81 95 819 7824 E-mail: ymitsui@nagasaki-u.ac.jp
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Abstract

The effect of artesunate (ART) on the survival time of adult worm pairs of Schistosoma mansoni and on their egg output during in vitro culture was assessed. ART significantly decreased the survival time of both paired male and female worms at concentrations of 5, 10, 20 and 40 mg l− 1 during in vitro cultivation. An inhibitory effect of ART on the daily egg output of paired female worms during in vitro cultivation was also observed.

Type
Research Papers
Information
Journal of Helminthology , Volume 83 , Issue 1 , March 2009 , pp. 7 - 11
Copyright
Copyright © Cambridge University Press 2009

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