Genetical Research



The detection of shared and ancestral polymorphisms


BRIAN CHARLESWORTH a1c1, CAROLINA BARTOLOMÉ a1p1 and VÉRONIQUE NOËL a1
a1 Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, King's Buildings, Edinburgh EH9 3JT, UK

Article author query
charlesworth b   [PubMed][Google Scholar] 
bartolome c   [PubMed][Google Scholar] 
noel v   [PubMed][Google Scholar] 

Abstract

There is increasing evidence that closely related species contain many polymorphisms that were present in their common ancestral species. Use of a more distant relative as an outgroup increases the ability to detect such ancestral polymorphisms. We describe a method for further improving estimates of the fraction of polymorphisms that are ancestral, and illustrate this with reference to data on Drosophila pseudoobscura and D. miranda. We also derive formulae for the proportion of fixations arising from ancestral polymorphisms and new mutations, respectively. The results should be useful for tests of selection based on the levels of expected and observed ancestral polymorphisms.

(Received March 18 2005)
(Revised August 1 2005)


Correspondence:
c1 Tel: 0131-650-5750. Fax: 0131-650-6564. e-mail: Brian.Charlesworth@ed.ac.uk
p1 Present address: Unidade de Xenética Evolutiva, Instituto de Medicina Legal, Facultade de Medicina, Universidade de Santiago de Compostela, 15782- Santiago de Compostela, Spain.


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