Parasitology



Subversion of immune cell signal transduction pathways by the secreted filarial nematode product, ES-62


W. HARNETT a1c1, H. S. GOODRIDGE a2 and M. M. HARNETT a2
a1 Department of Immunology, University of Strathclyde, Glasgow G4 0NR, UK
a2 Division of Immunology, Infection and Inflammation, University of Glasgow, G11 6NT, UK

Article author query
harnett w   [PubMed][Google Scholar] 
goodridge hs   [PubMed][Google Scholar] 
harnett mm   [PubMed][Google Scholar] 

Abstract

Filarial nematodes achieve longevity within the infected host by suppressing and modulating the host immune response. To do this, the worms actively secrete products that have been demonstrated to possess immunomodulatory properties. In this article we discuss the immunomodulatory effects of the phosphorylcholine-containing filarial nematode secreted glycoprotein ES-62. In particular we describe how it modulates intracellular signal transduction pathways in a number of different cells of the immune system, in particular B-lymphocytes, T-lymphocytes, macrophages and dendritic cells.


Key Words: ES-62; filarial nematode; immune system cells; signal transduction.

Correspondence:
c1 Department of Immunology, University of Strathclyde, Glasgow G4 0NR, UK. Tel: 0141-548-3725. Fax: 0141-548-3427. E-mail: w.harnett@strath.ac.uk


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