International Psychogeriatrics

Dementia associated with toxic causes and autoimmune disease

Peter Schofield a1c1
a1 Neuropsychiatry Service, Hunter Area Health and University of Newcastle, NSW, Australia

Article author query
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Toxic causes of dementia include exposure to heavy metals such as lead, mercury and aluminum as well as to carbon monoxide and solvents. Autoimmune conditions include such entities as multiple sclerosis, systemic lupus erythematosus, Behçet's disease and Sjögren's syndrome. These conditions share broadly similar cognitive effects giving rise to impairments with subcortical features. Individuals are often affected at a relatively young age. Optimal preventative strategies include avoidance of toxic substances. Comprehensive neuropsychological assessment is valuable not only diagnostically and for monitoring but also to identify the patients' strengths and weaknesses, so that compensatory strategies can be recommended.

Key Words: Dementia; cognitive impairment; autoimmune; neurotoxicology.

c1 Correspondence should be addressed to: Peter Schofield, PO Box 833, Newcastle, NSW 2300, Australia. Phone: +61-02-49246857; Fax: +61-02-49246849. Email: