Behavioral and Brain Sciences



open peer commentary

adhd theories still need to take more on board: serotonin and pre-executive variability


robert d. oades a1 and hanna christiansen a1
a1 university clinic for child and adolescent psychiatry, 45147 essen, germany oades@uni-essen.de hanna.christiansen@uni-essen.de http://www.biopsychology.uni-essen.de

Abstract

correcting the relationship between tonic and burst firing modes in dopamine neurons may help normalise stimulus-reinforcement gradients and contingent behaviour in attention-deficit/hyperactivity disorder (adhd) children. but appropriate evaluations of stimuli for developing adaptive plans and controlling impulsivity will not occur without moderating the gain-like functions of serotonin. the “dynamic theory” correctly highlights the need to account for variability in adhd. the dysmaturation of pre-executive information processing is proposed as an explanation.

at the core of the article by sagvolden and colleagues there is a set of data that throws light on an aspect of the adhd phenomenon. but one asks if the authors are a measure too brave to generalise so broadly from the unusually steep reinforcement gradients reported for the human condition and an animal model to the syndrome as a whole.



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