Fetal and Maternal Medicine Review



PARVOVIRUS B19 INFECTION IN PREGNANCY


BERNARD J COHEN a1c1 and SAILESH KUMAR a2
a1 Centre for Infections, Health Protection Agency, London
a2 Centre for Fetal Care, Queen Charlotte's and Chelsea Hospital, Imperial College London

Article author query
cohen bj   [PubMed][Google Scholar] 
kumar s   [PubMed][Google Scholar] 

Parvoviruses are widespread in nature, with a diversity of virus types affecting many animal species, usually in a species-specific manner. Some members of the parvovirus family give rise to asymptomatic infections but others are highly pathogenic, causing disease not only in adults but also in the young, the newborn and in the fetus. Parvoviruses of animals have for long been regarded as agents of reproductive failure and parvovirus B19 was recognised as a cause of fetal loss in humans in the 1980s. Moreover, following the control of congenital rubella by pre-pubertal and child vaccination, parvovirus B19 infection has emerged as probably the leading cause of viral embryopathy. This review will focus on the laboratory diagnosis of parvovirus B19 infection following exposure in pregnancy. The indications for testing maternal and fetal samples and the interpretation of test results will be discussed and a section is included on clinical management of the infection in pregnancy. The obstetric outcome in pregnant women who seroconvert will be reviewed.


Correspondence:
c1 Bernard J Cohen, Clinical Scientist, Virus Reference Department, Centre for Infections, Health Protection Agency, Colindale Avenue, London NW9 5HT.