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Serological evidence for the co-circulation of multiple dengue virus serotypes in Singapore

Published online by Cambridge University Press:  22 February 2005

ANNELIES WILDER-SMITH
Affiliation:
Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore
SUTEE YOKSAN
Affiliation:
Centre for Vaccine Development, Institute of Science and Technology for Research and Development, Mahidol University at Salaya, Nakhonpathom, Thailand
ARUL EARNEST
Affiliation:
Department of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore
RAVATHI SUBRAMANIAM
Affiliation:
Infectious Disease Research Centre, Tan Tock Seng Hospital, Singapore
NICHOLAS I. PATON
Affiliation:
Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore
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Abstract

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We did a seroepidemiological study to determine the circulating dengue virus serotypes and the extent to which the Singapore population has been exposed to multiple dengue virus serotypes, using the plaque reduction neutralization assay (PRNT). Of 164 enrolled subjects aged between 18–30 years, 49 subjects (29·8%) were PRNT positive for at least one dengue serotype. The seroprevalence was 39 (23·8%) for dengue virus serotype 1, 37 (22·6%) for type 2, 43 (26·2%) for type 3, and 30 (18·3%) for type 4. Of the 49 subjects with PRNT-positive dengue virus results, 28 (57·1%) were positive to all four virus serotypes, seven (14·3%) to three serotypes, two (4%) to two serotypes, and 12 (24·5%) to a single serotype. All four dengue virus serotypes circulate in Singapore, and a substantial proportion of the adult population in Singapore had exposure to more than one dengue virus serotype. In spite of multiple circulating types, the rate of dengue haemorrhagic fever is low in Singapore.

Type
Research Article
Copyright
2005 Cambridge University Press