Behavioral and Brain Sciences

Short Communication

Resistance to interference and the emergence of delayed gains in newly acquired procedural memories: Synaptic and system consolidation?

Maria Korman a1, Tamar Flash a2 and Avi Karni a3
a1 Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel, 76100
a2 Department of Computer Science, Weizmann Institute of Science, Rehovot, Israel, 76100
a3 Brain Behavior Research Center, University of Haifa, Israel, 31905


The progressive multistage stabilization of memory (consolidation) relies on post-acquisition neural reorganization. We hypothesize that two processes subserve procedural memory consolidation and are reflected in delayed post-acquisition performance gains: (1) synaptic consolidation, which is classical Hebbian, and (2) in some tasks, concurrently or consequently, “system consolidation,” which might in some skills be sleep-dependent. Behavioral interference may affect either type of consolidation.