Behavioral and Brain Sciences

Short Communication

Molecular mechanisms of synaptic consolidation during sleep: BDNF function and dendritic protein synthesis

Clive R. Bramham a1
a1 Department of Biomedicine and Locus on Neuroscience, University of Bergen, N-5009 Bergen, Norway


Insights into the role of sleep in the molecular mechanisms of memory consolidation may come from studies of activity-dependent synaptic plasticity, such as long-term potentiation (LTP). This commentary posits a specific contribution of sleep to LTP stabilization, in which mRNA transported to dendrites during wakefulness is translated during sleep. Brain-derived neurotrophic factor may drive the translation of newly transported and resident mRNA.