Cortico – (thalamo) – cortical interactions, gamma resonance, and auditory hallucinations in schizophrenia
|Ralph E. Hoffman a1, Daniel H. Mathalon a2, Judith M. Ford a3 and John H. Krystal a4|
a1 Department of Psychiatry, Yale University School of Medicine, Yale–New Haven Psychiatric Hospital, New Haven, CT 06519
a2 Department of Psychiatry, Yale University School of Medicine, Psychiatry Service 116A, VA Connecticut Healthcare System, West Haven, CT 06516
a3 Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305-5550
a4 Department of Psychiatry, Yale University School of Medicine, Ribicoff Research Facilities, CMHC, New Haven, CT 06519
Transcranial magnetic stimulation, EEG, and behavioral studies by our group implicate spurious activation of speech perception neurocircuitry in the genesis of auditory hallucinations in schizophrenia. The neurobiological basis of these abnormalities remains uncertain, however. We review our ongoing studies, which suggest that altered cortical coupling underlies speech processing in schizophrenia and is expressed via disrupted gamma resonances and impaired corollary discharge function of self-generated verbal thought.