Auditory hallucinations, network connectivity, and schizophrenia
Ralph E. Hoffman a1, Maxine Varanko a1, Thomas H. McGlashan a1andMichelle Hampson a2 a1 Department of Psychiatry, Yale University School of Medicine, Yale-New Haven Psychiatric Hospital, New Haven, CT 06519
[email protected][email protected][email protected] a2 Department of Diagnostic Radiology, Yale University School of Medicine, New Haven CT 06520-8043
Multidisciplinary studies indicate that auditory hallucinations may arise from speech perception neurocircuitry without disrupted theory of mind capacities. Computer simulations of excessive pruning in speech perception neural networks provide a model for these hallucinations and demonstrate that connectivity reductions just below a “psychotogenic threshold” enhance information processing. These data suggest a process whereby vulnerability to schizophrenia is maintained in the human population despite reproductive disadvantages of this illness.