Behavioral and Brain Sciences

Open Peer Commentary
Findlay & Walker: Saccade generation

Dopamine and impairment at the executive level

Trevor J. Crawford a1, Annelies Broerse a2 and Jans Den Boer a2
a1 Mental Health & Neural System Research Unit, Department of Psychology, Lancaster University, Lancaster, LA1 4YF, United Kingdom
a2 Department of Biological Psychiatry, State University of Groningen, 9700RB Groningen, The Netherlands


Patients with schizophrenia have an impairment in the inhibition of reflexive saccades, as a consequence of a functional impairment of the prefrontal cortex, which has not yet been encapsulated in terms of a formal model. A number of novel and testable hypotheses can be generated from the framework proposed by Findlay & Walker that will stimulate further research. Their framework therefore marks an important step in the development of a comprehensive functional model of saccadic eye movements. Further advances will be assisted by (1) a recognition of important distinctions in the executive control of volitional saccades and (2) addressing the capacity for cross-model integration of spatial information in the generation of the spatial properties of saccadic eye movements.