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Dopamine and impairment at the executive level

Published online by Cambridge University Press:  01 August 1999

Trevor J. Crawford
Affiliation:
Mental Health & Neural System Research Unit, Department of Psychology, Lancaster University, Lancaster, LA1 4YF, United Kingdomt.crawford@lancaster.ac.uk
Annelies Broerse
Affiliation:
Department of Biological Psychiatry, State University of Groningen, 9700RB Groningen, The Netherlandsj.a.den.boer@med.rug.nl
Jans Den Boer
Affiliation:
Department of Biological Psychiatry, State University of Groningen, 9700RB Groningen, The Netherlandsj.a.den.boer@med.rug.nl

Abstract

Patients with schizophrenia have an impairment in the inhibition of reflexive saccades, as a consequence of a functional impairment of the prefrontal cortex, which has not yet been encapsulated in terms of a formal model. A number of novel and testable hypotheses can be generated from the framework proposed by Findlay & Walker that will stimulate further research. Their framework therefore marks an important step in the development of a comprehensive functional model of saccadic eye movements. Further advances will be assisted by (1) a recognition of important distinctions in the executive control of volitional saccades and (2) addressing the capacity for cross-model integration of spatial information in the generation of the spatial properties of saccadic eye movements.

Type
Open Peer Commentary
Copyright
© 1999 Cambridge University Press

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