Open Peer Commentary Aggleton & Brown: Episodic memory, amnesia, and hippocampus
The gap between episodic memory and experiment: Can c-fos expression replace recognition testing?
Jan Bures a1andAndre A. Fenton a1 a1 Institute of Physiology, Academy of Sciences, 14220 Prague, Czech Republic
bures@biomed.cas.cz
Abstract
The effort to identify the neural substrate of episodic
recall, though ambitious, lacks experimental support. By considering
the data on c-fos activation by novel and familiar stimuli in
recognition studies, we illustrate how inadequate experimental designs
permit alternative interpretations. We stress that interpretation of
c-fos expression changes should be supported by adequate
recognition tests.
