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Adsorption of sufentanil to epidural filters and catheters

Published online by Cambridge University Press:  02 June 2005

M. Westphal
Affiliation:
University of Münster, Department of Anaesthesiology and Intensive Care, Münster, Germany
H. Hohage
Affiliation:
University of Münster, Department of Internal Medicine, Münster, Germany
H. Buerkle
Affiliation:
University of Münster, Department of Anaesthesiology and Intensive Care, Münster, Germany
H. Van Aken
Affiliation:
University of Münster, Department of Anaesthesiology and Intensive Care, Münster, Germany
T. Ermert
Affiliation:
University of Münster, Department of Anaesthesiology and Intensive Care, Münster, Germany
and G. Brodner
Affiliation:
University of Münster, Department of Anaesthesiology and Intensive Care, Münster, Germany
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Abstract

Summary

Background and objective: Stable drug concentrations must be administered to provide adequate patient-controlled epidural analgesia. This study investigated the stability of sufentanil after the epidural delivery system had been flushed with solutions containing the drug.

Methods: Sufentanil citrate, 5 μg mL−1 was injected through an epidural catheter system into a glass container. The concentrations of the drug leaving the system, in 1 mL aliquots (1–5 mL) were measured using high-performance liquid chromatography. In the same manner, sufentanil samples were analysed after flushing the filter, as well as after priming the filter and catheter.

Results: ANOVA for repeated measurements demonstrated that sufentanil concentrations remained constant as long as the catheter had been adequately flushed. However, the concentration of sufentanil in the solution exiting the filter was reduced significantly. Hardly any sufentanil could be detected (0.09 ± 0.01 μg mL−1, P < 0.001) in the first 1 mL aliquot (probe) leaving the filter. Altogether, 3 mL sufentanil solution was needed to pass through the filter before the baseline values were restored (P < 0.05). The greatest decrease occurred when the whole epidural delivery apparatus (catheter and filter) was primed; to regain baseline values, as much as 4 mL solution was needed to flush the system.

Conclusions: Sufentanil citrate is adsorbed by the materials used to manufacture systems (catheters, filters) used in epidural anaesthesia. Hence, the epidural catheter system should be primed with sufentanil before connecting it to the patient so as to deliver reliable concentrations.

Type
Original Article
Copyright
2003 European Society of Anaesthesiology

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References

Brodner G, Mertes N, Buerkle H, Marcus MA, Van Aken H. Acute pain management: analysis, implications and consequences after prospective experience with 6349 surgical patients. Eur J Anaesthesiol 2000; 17: 566575.Google Scholar
Brodner G, Mertes M, Van Aken H, et al. What concentration of sufentanil should be combined with ropivacaine 0.2% wt/vol for postoperative patient-controlled epidural analgesia? Anesth Analg 2000; 90: 649657.Google Scholar
Brodner G Mertes N Van Aken H, et al. Epidural analgesia with local anesthetics after abdominal surgery: earlier motor recovery with 0.2% ropivacaine than 0.175% bupivacaine. Anesth Analg 1999; 88: 128133.Google Scholar
Polley LS, Columb MO. Comparison of epidural ropivacaine and bupivacaine in combination with sufentanil for labor. Anesthesiology 2000; 92: 772778.Google Scholar
Baldwin ES, Turner MA. Profound motor blockade with epidural ropivacaine. Anaesthesia 2000; 55: 91.Google Scholar
Roos PJ, Glerum JH, Meilink JW. Stability of sufentanil citrate in a portable pump reservoir, a glass container and a polyethylene container. Pharm Weekbl Sci 1992; 14: 196200.Google Scholar
Roos PJ, Glerum JH, Meilink JW, Zwang L. Effect of pH on absorption of sufentanil citrate in a portable pump reservoir during storage and administration under simulated epidural conditions. Pharm World Sci 1993; 15: 139144.Google Scholar
Roos PJ, Glerum JH, Schroeders MJ. Effect of glucose 5% solution and bupivacaine hydrochloride on absorption of sufentanil citrate in a portable pump reservoir during storage and simulated infusion by an epidural catheter. Pharm World Sci 1993; 15: 269175.Google Scholar
Brodner G, Ermert T, Van Aken H, et al. Stability of sufentanil–ropivacaine mixture in a glass and PVC reservoir. Eur J Anaesthesiol 2002; 19: 295297.Google Scholar
Movig KL, Langen MC, Egberts AC. Analysis of low concentration sufentanil citrate/bupivacaine hydrochloride admixtures, using solid phase extraction followed by high-performance liquid chromatography. J Pharm Biomed Anal 1999; 21: 845850.Google Scholar