Epidemiology and Infection

Short Report

Food poisoning and gastroenteritis

Surveillance of antimicrobial resistance of Salmonella enterica serotype Typhi in seven Asian countries

C.-H. CHUANGa1a2, L.-H. SUa1, J. PERERAa3, C. CARLOSa4, B. H. TANa5, G. KUMARASINGHEa5, T. SOa6, P. H. VANa7, A. CHONGTHALEONGa8, P.-R. HSUEHa9, J.-W. LIUa10, J.-H. SONGa11 and C.-H. CHIUa1 c1

a1 Chang Gung Children's Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan

a2 St Paul's Hospital, Taoyuan, Taiwan

a3 University of Colombo, Colombo, Sri Lanka

a4 Research Institute for Tropical Medicine, Manila, Philippines

a5 Singapore General Hospital, National University of Singapore, Singapore

a6 Princess Margaret Hospital, Hong Kong, P.R. China

a7 University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam

a8 Chulalongkorn University, Bangkok, Thailand

a9 National Taiwan University Hospital, Taipei, Taiwan

a10 Chang Gung Memorial Hospital, Kaohsiung, Taiwan

a11 Samsung Medical Center, Seoul, Korea


Two hundred and four Salmonella enterica serotype Typhi (S. Typhi) isolates were collected from seven Asian countries during 2002–2004. Multidrug-resistant S. Typhi (resistant to xs2A7E3 antibiotics) was detected in 84 (41·2%) isolates and 142 (69·6%) showed reduced susceptibility to ciprofloxacin (minimum inhibitory concentration=0·125–1·0 mg/l). This study highlights the worsening situation of antimicrobial resistance of S. Typhi in Asia.

(Accepted April 09 2008)

(Online publication May 12 2008)


c1 Author for correspondence: C.-H. Chiu, M.D., Ph.D., Department of Pediatrics, Chang Gung Children's Hospital, 5 Fu-Hsin Street, Kweishan 333, Taoyuan, Taiwan. (Email: chchiu@adm.cgmh.org.tw)