Behavioral and Brain Sciences

Open Peer Commentary
Fitch & Denenberg: Sexual differentiation of the brain

Estrogens in human psychosexual differentiation

Heino F. L. Meyer-Bahlburg a1
a1 New York State Psychiatric Institute and Department of Psychiatry of Columbia University, New York, NY 10032


There is some very limited evidence for a role of estrogens in human psychosexual masculinization; its interpretation is uncertain. Fitch & Denenberg's demonstration of a role for estrogens in the behavioral feminization of nonhuman mammals implicitly suggests an answer to a riddle posed by the syndrome of congenital adrenal hyperplasia in women.